Kyäni Nitro FXTM and Kyäni Nitro XtremeTM: The Science Behind Kyäni’s Nitric Oxide Precursors
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Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages
Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...
متن کاملOriginal Contributions Neural Mechanism of Hypertension by Nitric Oxide Synthase Inhibitor in Dogs
This study aimed to determine the mechanism of hypertension associated with nitric oxide synthase inhibition. Intravenous injections of JV-nitro-L-arginine, a nitric oxide synthase inhibitor, produced a sustained increase in systemic blood pressure and a decrease in heart rate in anesthetized dogs, whereas iV-nitro-D-arginine had no effect. L-Arginine reversed the pressor response. yV-Nitro-L-a...
متن کاملThe Role of Nitric Oxide Synthase in Endotoxin-Induced Uveitis: Effects of N-Nitro L-Arginine
Methods. EIU was caused in Lewis rats by injecting lipopolysaccharide (LPS) into the foot pad, and the effects of an NOS inhibitor, N-nitro L-arginine (NA), was comparatively studied by the simultaneous administration of NA and LPS. Total NOS and inducible NOS (iNOS) activities were differentially assayed in the anterior segment of the eye in EIU with and without NA treatment. The effects of NA...
متن کاملThe Possible Involvement of Nitric Oxide/Endothelium Derived Relaxing Factor in Atropine-Induced Vasorelaxation
Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...
متن کاملUpon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester.
8-Nitro-cGMP was recently discovered as a second messenger of nitric oxide. We describe here the synthesis and properties of DMACM-modified 8-nitro-cGMP for photochemical uncaging. Owing to the limited photostability of 8-nitro-cGMP care must be taken, but the photorelease of the intact product was readily feasible. Unexpectedly, 8-nitro-cGMP decays under formation of 8-nitrosoguanine when irra...
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